Short children with impaired growth hormone secretion
نویسندگان
چکیده
منابع مشابه
Defective growth hormone secretion in children with pycnodysostosis and improved linear growth after growth hormone treatment.
Short stature is a characteristic feature of pycnodysostosis. We report defective growth hormone secretion in response to provocation and low insulin-like growth factor-I (IGF-I) concentration in five out of six patients with pycnodysostosis. Physiological replacement with growth hormone increased IGF-I concentration and improved linear growth in these children.
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The serum growth hormone response to Bovril was studied in 12 growth-retarded children with severe asthma, and was found to be normal. Eight children who were receiving corticosteroids had been small for their age before starting steroid treatment. It is concluded that there is no case for treating growth-retarded asthmatic children with growth hormone.
متن کاملGrowth Hormone in the Treatment of Children with Short Stature
Therapeutic use of growth hormone (GH) in the United States generally has been restricted to GHdeficient children who, with their families, agree to participate in research. The limited supply and the considerable expense of commercially prepared GH have restricted the number of children who have received such therapy. As the medical community and public become more aware of the therapeutic pot...
متن کاملGrowth Hormone in the Treatment of Children with Short Stature
Therapeutic use of growth hormone (GH) in the United States generally has been restricted to GHdeficient children who, with their families, agree to participate in research. The limited supply and the considerable expense of commercially prepared GH have restricted the number of children who have received such therapy. As the medical community and public become more aware of the therapeutic pot...
متن کاملGrowth hormone receptor mutations in children with idiopathic short stature.
Homozygous or compound heterozygous mutations in the GH receptor (GHR) gene result in GH insensitivity syndrome. Previous reports have shown that some heterozygous mutations may induce a partial insensitivity to GH, but others appear to have limited effect on growth. To investigate further these observations, we analyzed the GHR gene in 17 subjects with idiopathic short stature (ISS). All subje...
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ژورنال
عنوان ژورنال: Saudi Medical Journal
سال: 2020
ISSN: 0379-5284,1658-3175
DOI: 10.15537/smj.2020.1.24785